Marazuela, PaulaBonaterra Pastra, AnnaFaura, JúliaPenalba, AnnaPizarro, JesúsPancorbo, OlallaRodríguez Luna, DavidVert, CarlaRovira, AlexPujadas, FrancescFreijo, M. MarTur, SilviaMartínez Zabaleta, MaiteCardona Portela, PereVera, RocíoLebrato Hernández, LuciaArenillas, Juan F.Pérez Sánchez, SoledadMontaner, JoanDelgado, PilarHernández Guillamon, Mar2021-04-072021-04-072021-03-02https://hdl.handle.net/2445/175995Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 +/- 18.6 months) and long-term (38.5 +/- 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as >= 2 lobar ICHs and >= 5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.15 p.application/pdfengcc by (c) Marazuela et al., 2021http://creativecommons.org/licenses/by/3.0/es/HemorràgiaMalalties del sistema nerviós centralRessonància magnèticaHemorrhageCentral nervous system diseasesMagnetic resonanceinfo:eu-repo/semantics/article2021-03-25info:eu-repo/semantics/openAccess33801197