Torres Martí, AntoniMotos, AnaRiera, JordiFernández Barat, LaiaCeccato, AdrianPérez Arnal, RaquelGarcía Gasulla, DarioPeñuelas, OscarLorente, José AngelRodriguez Oviedo, AlejandroGonzalo Calvo, David deMoral Parras, PedroAgrifoglio, AlexanderPiñol-tena, ÀngelsGarcía, BeatrizMaseda, EmilioMenor Fernández, Eva MaríaVilanova, JuditHuerta, ArturoMiralbés, MarÚbeda, AlejandroCachafeiro, LuciaEstella, ÁngelParera Pous, AnnaCliment, CristinaYang, MinlanSocias, LorenzoVillada Warrington, TatianaÁlvarez, SergioCarbajales Pérez, CristinaMorales, DulceBarberà, CarmeRodriguez, LauraAlcaraz Serrano, VictoriaMariño, Ana BalanAlmansa Mora, RaquelOrtega, AnaConde, PamelaAguilar Cabello, MaríaPujol, AndrésRubio, JorgeÁngel, JoséCicuendez Ávila, RamonMendoza, Diego deSoliva, LauraMacias Guerrero, DesireRamon Coll, NúriaRenedo Sanchez-Giron, GloriaLoza Vázquez, AnaAlegre, CynthiaRoche Campo, FerranAguilera, LucianoSariñena, Maria TeresaGomà, GemmaMartínez Varela, IgnacioBarbeta, EnricMarin Corral, JudithBouza Vieiro, María TeresaSuares Sipmann, FernandoBlandino Ortiz, AaronSancho Chinesta, SusanaCantón Bulnes, Maria LuisaAlbaiceta, Guillermo M.Sánchez, AnaGómez, SilviaBlancas, RafaelTognetti, DanielUrrelo Cerrón, LuisBustamante-munguira, JuanMenéndez, RosarioCodina, JordiClar, LuisaTormos, AdriánÁlvarez Ruiz, AntonjoBofill, NeusTorres, MateuBlasco Cortés, María LuisaVengoechea, JavierMarco Naya, GregorioCarvalho, SulaAndrea, RutBarral Segade, PatriciaMartin, María CruzBarbena, LauraForcelledo Espina, LorenaBadia, Joan RamonVázquez, NilMarmol Peis, EnriqueZapatero, AnaTorre, Maria del Carmen de laFernández, JavierGómez Casal, VanesaGascón Castillo, Maria LuisaCIBERESUCICOVID Project (COV20/00110, ISCIII)Bueno, LeticiaEsmorís Arijón, InésCarbonell, NievesGómez, José M.Mosquera Rodríguez, DavidGarcía, FelipeGarcía Garmendia, José LuisIglesias, SilviaSolé Violán, JordiSanchez, MiguelCatalán González, MercedesGalbán, CristóbalCardina Fernández, PabloForcadell Ferreres, EvaGumucio Sanguino, Víctor D.Boado, MaríaFarre Monjo, TeresaPeñasco, YhivianPérez Bastida, LeireCasacuberta Barberà, NúriaGonzález, JessicaCarrión García, LauraLeón, MiguelBusto Martínez, Cecilia delGarnacho Montero, JoséContreras, SofíaJuan Díaz, MarMarcos, PilarCastro, PedroLópez Messa, JuanPérez Planelles, GloriaJaner, Maria TeresaTamayo Lomas, LuisAldecoa, CésarLópez Lago, AnaPagliarani, PabloBardi, TommasoVara Adrio, SabelaTrenado Álvarez, JoséBarbé, FerranFranco, NievesLazo Álvarez, Juan I.Adell Serrano, BertaJiménez, GabrielBadía, MarionaSegura Pensado, MartaMartínez, MaríaFurro, ÀngelsMontserrat, NeusGracia, Maria PilarPablo Sánchez, Raul deGómez Gonzalez, CarmenMuñoz Bermúdez, RosanaGarcía Redruello, CarlosAyestaran, IgnacioSerra Fortuny, MireiaBarroso, MartaBodi Saera, MaríaMora Aznar, MaríaCillóniz, CatiaPérez, PurificaciónParrilla, FranciscoBerezo García, José ÁngelLópez Gavín, AlexandreMontejo González, Juan CarlosBigas, JuditCampos Fernández, SandraVidal Cortés, PabloNogueras Salinas, RafaelaFerrer Roca, RicardMartínez Fernández, Carmen EulaliaPestaña Laguna, DavidMartín Vicente, PaulaRuiz Miralles, MiriamMañez Mendiluce, RafaelCampi Hermoso, DavidCastellà Pericàs, ManuelEnríquez Giraudo, PedroRodríguez Ruiz, CovadongaSerra, LidiaBustamante Munguira, ElenaCastellví, AndreaAñón, José M.Rodríguez de Castro, FelipeDíaz, YolandaFigueras, AlbertSalazar Degracia, AnaGabarrús, AlbertCaballero, JesúsGordo, FedericoArrieta Ruiz, MartaRivas Vilas, María DignaDólera Moreno, CristinaNicolás Arfelis, Josep MariaRubio López, AlbertoDot, IreneRodríguez, SilviaGarcía Sagastume, AmaiaRicart, PilarOcón, MartaServià, LluísNogue Bou, RamonValdivia Ruiz, LuisPrados, JavierFerrando, CarlosPérez Rubio, EvaVilà Vilardel, ClaraOssa, SergioGarcía Prieto, EmilioSánchez Miralles, AngelTrefler, SandraHerraiz, AlbaKiarostami, KarsaVan Der Hofstadt Martin-Montalvo, MariaNovo, Mariana AndreaAmaya Villar, RosarioBermejo Martín, Jesús F.Herrán Monge, RubénRyan Murúa, PabloVal, EstelaIbarz, MercedesTrujillano, JavierMantellini, Cecilia L.Báez Pravia, OrvilleYang, HuaSaborido Paz, EvaSpeziale, CarlaBarberán, JoséSerrano Lázaro, AinhoaJorge García, Ruth NoemíSantacoloma, BitorMamolar Herrera, NuriaBalsera, BegoñaMartínez Juan, Maria DoloresMonclou, JosmanGallego, ElenaSalvador Adell, InmaculadaPozo Laderas, Juan CarlosMasa Jimenez, Juan FernandoVallverdú, MontserratDíaz Santos, EmiliMasclans, Joan RamonMoreno Cano, Sara GuadalupeCano, IosuneMartínez de la Gándara, Amalia2021-10-112021-10-112021-09-131364-8535https://hdl.handle.net/2445/180518Following publication of the original article at https://doi.org/10.1186/s13054-021-03727-x the authors identified an error in the Funding section that has been corrected (https://doi.org/10.1186/s13054-021-03849-2)Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation.13 p.application/pdfengcc by (c) Torres Martí, Antoni et al, 2021http://creativecommons.org/licenses/by/3.0/es/COVID-19Respiració artificialPronòstic mèdicCOVID-19Artificial respirationPrognosisinfo:eu-repo/semantics/article7188087211182021-10-07info:eu-repo/semantics/openAccess34517881