Abraham, Michael H.Acree Jr, William E.Pérez Ràfols, ClaraRosés Pascual, Martí2022-04-132022-04-132021-04-010095-9782https://hdl.handle.net/2445/184953We use literature data on solubilities of 46 compounds in the water-isopropanol (IPA) system to obtain the corresponding partition coefficients, P, for transfer from water to water- IPA mixtures. We have then used our previously constructed linear free energy equation to obtain equations that correlate log10 P at water-IPA intervals across the entire water-IPA system. These equations can then be used to predict partition coefficients and solubilities of further compounds in the water-IPA systems at 298 K. The coefficients in our linear free energy equation encode information on the physicochemical properties of the water- IPA mixtures. We show that the hydrogen bond basicity of the water-IPA mixtures only increases slightly from water to IPA, but that the hydrogen bond acidity of the mixtures decreases markedly from water to IPA in a smooth continuous manner. We have also used data on ions and on ionic species to set out equations for the estimation of their partition coefficients from water to water-IPA mixtures. We find that for partition from water to IPA itself, log10 P = − 1.81 for H+.15 p.application/pdfeng(c) Springer Verlag, 2021SolubilitatAlcoholsIonitzacióSolubilityAlcoholsIonizationinfo:eu-repo/semantics/article7181302022-04-13info:eu-repo/semantics/openAccess