Herraiz Cobo, JesúsAlbericio Palomera, FernandoÁlvarez Domingo, Mercedes2015-06-042015-06-042015-12-120065-2725https://hdl.handle.net/2445/65732The indole ring is one of the most common features in natural products and small molecules with important bioactivity. Larock reported a new methodology for the synthesis of the indole ring system based on the palladium-catalyzed heteroannulation of 2-iodoaniline and substituted alkyne moieties. This procedure was subsequently extended to the preparation of other nitrogen- and oxygen- containing heterocycles. This is the process of choice for the synthesis of a large number of heterocyclic derivatives, as it provides outstanding regioselectivity and good to excellent yields.46 p.application/pdfeng(c) Elsevier, 2015Química orgànicaSíntesi orgànicaCompostos heterocíclicsOrganic chemistryOrganic synthesisHeterocyclic compoundsinfo:eu-repo/semantics/article6492272015-06-04info:eu-repo/semantics/openAccess