Gensthaler, LisaJoura, Elmar A.Alemany i Vilches, LaiaHorvat, ReinhardSanjosé Llongueras, Silvia dePils, Sophie2021-01-202021-01-202020-03-01https://hdl.handle.net/2445/173258Purpose To evaluate HPV and p16(ink4a) status as prognostic factors in patients with invasive vulvar cancer. Methods Retrospective analysis of disease-free (DFS) and disease-specific survival (DSS) of patients with invasive vulvar cancer at a single tertiary care center. Histology, HPV and p16(ink4a) status were evaluated in the context of a global multicenter trial. Logistic regression models were performed to identify the impact of p16(ink4a) positivity. Results 135 patients were included in the analysis. 32 (23.7%) showed a p16(ink4a) expression of over 25%. Disease-free and disease-specific survival was longer in p16(ink4a) positive patients (23 vs. 10 months, p = 0.004, respectively, 29 vs. 21 months, p = 0.016). In multivariate analysis, p16(ink4a) positivity was an independent parameter for DFS (p = 0.025, HR: 2.120 (1.100-4.085)), but not for DSS (p = 0.926, HR: 1.029 (0.558-1.901), in contrast to age and tumor stage. Conclusions Age and tumor stage negatively affect survival. However, disease-free survival is significantly longer in patients with p16(ink4a) positive invasive vulvar cancer.6 p.application/pdfengcc by (c) Gensthaler et al., 2020http://creativecommons.org/licenses/by/3.0/es/Papil·lomavirusCàncer ginecològicPronòstic mèdicPapillomavirusesGynecologic cancerPrognosisinfo:eu-repo/semantics/article2020-12-21info:eu-repo/semantics/openAccess31970493