Perelló Bratescu, AinaDürsteler, ChristianÁlvarez Carrera, Maria AsunciónGranés, LauraKostov, BelchinSisó Almirall, Antoni2023-08-022023-08-022022-01-201999-4923https://hdl.handle.net/2445/201469In chronic non-cancer pain (CNCP), evidence of the effectiveness of strong opioids (SO) is very limited. Despite this, their use is increasingly common. To examine SO prescriptions, we designed a descriptive, longitudinal, retrospective population-based study, including patients aged >= 15 years prescribed SO for >= 3 months continuously in 2013-2017 for CNCP in primary care in Catalonia. Of the 22,691 patients included, 17,509 (77.2%) were women, 10,585 (46.6%) were aged >80 years, and most had incomes of <euro18,000 per year. The most common diagnoses were musculoskeletal diseases and psychiatric disorders. There was a predominance of transdermal fentanyl in the defined daily dose (DDD) per thousand inhabitants/day, with the greatest increase for tapentadol (312% increase). There was an increase of 66.89% in total DDD per thousand inhabitants/day for SO between 2013 (0.737) and 2017 (1.230). The mean daily oral morphine equivalent dose/day dispensed for all drugs was 83.09 mg. Transdermal fentanyl and immediate transmucosal release were the largest cost components. In conclusion, there was a sustained increase in the prescription of SO for CNCP, at high doses, and in mainly elderly patients, predominantly low-income women. The new SO are displacing other drugs.10 p.application/pdfengcc by (c) Perelló Bratescu, Aina et al., 2022http://creativecommons.org/licenses/by/3.0/es/OpiacisAvaluació del risc per la salutTractament del dolorOpioidsHealth risk assessmentPain treatmentinfo:eu-repo/semantics/article2023-07-04info:eu-repo/semantics/openAccess929932935213969