Abdel Monaim, Shimaa A. H.Noki, SikabweRamchuran, Estelle J.El-Faham, AymanAlbericio Palomera, Fernandode la Torre, Beatriz G.2020-04-142020-04-142017-09-281420-3049https://hdl.handle.net/2445/155311Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity.9 p.application/pdfengcc-by (c) Abdel Monaim, Shimaa A. H. et al., 2017http://creativecommons.org/licenses/by/3.0/esSíntesi de pèptidsBacterisMycobacterium tuberculosisPeptide synthesisBacteriaMycobacterium tuberculosisinfo:eu-repo/semantics/article6810582020-04-14info:eu-repo/semantics/openAccess28956840