Duque, María D.Torres Costa, EvaValverde Murillo, ElenaBarniol-Xicota, MartaGuardiola Bagán, SalvadorRey Carrizo, MatíasVázquez Cruz, Santiago2012-01-092012-01-092011https://hdl.handle.net/2445/21371Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392Influenza is a highly contagious, major respiratory tract disease affecting millions of people each year. At present, two classes of antivirals are available: the neuraminidase inhibitors and the M2 proton channel blockers amantadine and rimantadine. However, rapid emergence of M2 blockers resistance makes imperative the development of new anti-influenza drugs. In the last few years several groups have synthesized and evaluated several analogs of amantadine. While several of them are active against wild-type M2 channel only a few are able to inhibit the mutant ion channels that lead to amantadine-resistance.30 p.application/pdfeng(c) Transworld Research Network, 2011InfluenzavirusResistència als medicamentsInhibidors enzimàticsInfluenza virusesDrug resistanceEnzyme inhibitorsinfo:eu-repo/semantics/bookPart257179info:eu-repo/semantics/openAccess