Ciruela Alférez, FranciscoFuxe, KjellIlles, PeterUlrich, HenningCaciagli, Francesco2025-09-192025-09-192021-09-141663-9812https://hdl.handle.net/2445/223267The “purinergic signaling” term was coined in 1972 by Geoffrey Burnstock Burnstock et al. after demonstrating that adenosine 5’-triphosphate (ATP) is a transmitter in nonadrenergic, noncholinergic inhibitory nerves innervating the guinea-pig taenia coli (Burnstock et al., 1966). This signaling system, which is ubiquitously expressed in every organ and system of the body, comprises various ecto-, soluble and intracellularly localized enzymes, nucleoside transporters, and G protein-coupled and ligand-gated cation channel receptors. Through the purinergic signaling system cells can maintain basal adenine and guanine-based purines at certain steady-state levels, thereby contributing to preserve the purines-dependent cellular homeostasis.3 p.application/pdfengcc-by (c) Ciruela, F. et al., 2021http://creativecommons.org/licenses/by/4.0/Trifosfat d'adenosinaPurinesAnimalsAdenosine triphospahatasePurinesAnimalsinfo:eu-repo/semantics/publishedVersion7217952025-09-19info:eu-repo/semantics/openAccess