Campàs, O.Kafri, Y.Zeldovich, K.Casademunt i Viader, JaumeJoanny, J. F.2010-06-112010-06-1120060031-9007https://hdl.handle.net/2445/12844The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N * 5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.4 p.application/pdfeng(c) American Physical Society, 2006Dinàmica molecularMolecular dynamicsinfo:eu-repo/semantics/article548392info:eu-repo/semantics/openAccess