Ripollés, PabloFerreri, LauraMas-Herrero, ErnestAlicart, HelenaGómez Andrés, AlbaMarco Pallarés, JosepAntonijoan Arbós, Rosa Ma. (Rosa María)Noesselt, ToemmeValle, MartaRiba, JordiRodríguez Fornells, Antoni2020-01-152020-01-152018-09-302050-084Xhttps://hdl.handle.net/2445/147922We recently provided evidence that an intrinsic reward-related signal-triggered by successful learning in absence of any external feedback-modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success.23 p.application/pdfengcc-by (c) Ripollés, P. et al., 2018http://creativecommons.org/licenses/by/3.0/esAprenentatgeFisiologiaNeurotransmissióTransducció de senyal cel·lularLearningPhysiologyNeural transmissionCellular signal transductioninfo:eu-repo/semantics/article6825402020-01-15info:eu-repo/semantics/openAccess30160651