Rodríguez Ramírez, AleixAriza Piquer, XavierContreras, Miguel A.García Gómez, JordiLloyd-Williams, PaulMercadal, NereaSánchez Zarzalejo, Carolina2017-02-072018-02-032017-02-030022-3263https://hdl.handle.net/2445/106619Treatment of readily available allene 1 with Cy2BH followed by addition of an aldehyde led to quaternary protected 2-amino-2-vinyl-1,3-diols in high yield and excellent stereochemical purity. The choice of benzoyl as N-protecting group is critical since the observed N- to O-Bz transfer during the process prevents later undesired isomerizations in the adducts and keeps all heteroatoms protected.5 p.application/pdfeng(c) American Chemical Society , 2017Síntesi orgànicaAldehidsEsfingolípidsInhibidors enzimàticsOrganic synthesisAldehydesSphingolipidsEnzyme inhibitorsinfo:eu-repo/semantics/article6673882017-02-07info:eu-repo/semantics/openAccess28085287