Steward, TrevorMartínez Zalacaín, IgnacioMestre-Bach, GemmaSánchez Zaplana, IsabelRiesco, NadineJiménez-Murcia, SusanaFernández Formoso, Jose A.Veciana de las Heras, MisericordiaCustal, NuriaMenchón Magriñá, José ManuelSoriano Mas, CarlesFernández Aranda, Fernando2021-08-042021-08-042020-07-230033-2917https://hdl.handle.net/2445/179621Background: although deficits in affective processing are a core component of anorexia nervosa (AN), we lack a detailed characterization of the neurobiological underpinnings of emotion regulation impairment in AN. Moreover, it remains unclear whether these neural correlates scale with clinical outcomes. Methods: we investigated the neural correlates of negative emotion regulation in a sample of young women receiving day-hospital treatment for AN (n = 21) and healthy controls (n = 21). We aimed to determine whether aberrant brain activation patterns during emotion regulation predicted weight gain following treatment in AN patients and were linked to AN severity. To achieve this, participants completed a cognitive reappraisal paradigm during functional magnetic resonance imaging. Skin conductance response, as well as subjective distress ratings, were recorded to corroborate task engagement. Results: compared to controls, patients with AN showed reduced activation in the dorsolateral prefrontal cortex (dlPFC) during cognitive reappraisal [pFWE<0.05, threshold-free cluster enhancement (TFCE) corrected]. Importantly, psycho-physiological interaction analysis revealed reduced functional connectivity between the dlPFC and the amygdala in AN patients during emotion regulation (pFWE<0.05, TFCE corrected), and dlPFC-amygdala uncoupling was associated with emotion regulation deficits (r = -0.511, p = 0.018) and eating disorder severity (r = -0.565, p = .008) in the AN group. Finally, dlPFC activity positively correlated with increases in body mass index (r = 0.471, p = 0.042) and in body fat mass percentage (r = 0.605, p = 0.008) following 12 weeks of treatment. Conclusions: taken together, our findings indicate that individuals with AN present altered fronto-amygdalar response during cognitive reappraisal and that this response may serve as a predictor of response to treatment and be linked to clinical severity.9 p.application/pdfeng(c) Cambridge University Press, 2020Anorèxia nerviosaTrastorns de la conducta alimentàriaEmocionsAnorexia nervosaEating disordersEmotionsinfo:eu-repo/semantics/article7103492021-08-04info:eu-repo/semantics/openAccess32698931