Ferrer Fábrega, JoanaFolch i Puy, EmmaLozano Salvatella, Juan JoséVentura Aguiar, PedroCárdenas, GabrielParedes, DavidGarcía Criado, ÁngelesBombí, Josep AntoniGarcía Pérez, RocíoLópez Boado, Miguel ÁngelRull, RamónEsmatjes Mompó, EnricRicart Brulles, Ma. JoséDiekmann, FritzFondevila Campo, ConstantinoFernández Cruz, LaureanoFuster Obregón, JosepGarcía-Valdecasas Salgado, Juan Carlos2022-05-132022-05-132022-03-280934-0874https://hdl.handle.net/2445/185546Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n = 267), 10.8% of Celsior (CS) group (n = 83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n = 7), and none for Institut Georges Lopez-1 (IGL-1) group (n = 23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups. Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (p = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. Keywords: pancreas transplantation, graft survival, preservation solution, ischemia-reperfusion, pancreatitis,13 p.application/pdfengcc-by (c) Ferrer Fábrega, Joana et al., 2022https://creativecommons.org/licenses/by/4.0/Trasplantament d'òrgansConservació d'òrgansPàncreesTransplantation of organsPreservation of organsPancreasinfo:eu-repo/semantics/article7225242022-05-13info:eu-repo/semantics/openAccess9307854