Martínez-González, Miguel Ángel, 1957-Planes, Francisco J.Ruiz-Canela, MiguelToledo Atucha, EstefaníaEstruch Riba, RamonSalas Salvadó, JordiValdés Mas, RafaelMena, PedroCastañer, OlgaFitó Colomer, MontserratClish, Clary B.Landberg, RikardWittenbecher, ClemensLiang, LihuaGuasch Ferré, MartaLamuela Raventós, Rosa Ma.Wang, Dong D.Forouhi, NitaRazquin, CristinaHu, Frank B.2025-10-222025-10-222025-03https://hdl.handle.net/2445/223813A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: <em>a)</em> developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; <em>b)</em> incorporating more diverse populations and a broader range of dietary patterns; and <em>c)</em> conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.9 p.application/pdfengcc-by-nc-nd (c) Miguel Ángel Martínez-González, et al., 2025http://creativecommons.org/licenses/by-nc-nd/4.0/Malalties cardiovascularsNutricióCardiovascular diseasesNutritioninfo:eu-repo/semantics/article7608072025-10-22info:eu-repo/semantics/openAccess