Martín Andorrà, MargaritaGuo, YanruUniversitat de Barcelona. Departament de Biomedicina2025-09-192025-09-192023-07-20https://hdl.handle.net/2445/223265[eng] Anaphylaxis is a severe allergic reaction triggered by allergens to certain foods, medicines, insect venom, and other substances. Anaphylactic shock can be fatal if not treated. Mast cells are the effector cells in anaphylaxis, and mast cell transcriptional factors are crucial in controlling the production of mediators. In summary, this thesis shows the relevance of microphthalmia associatedtranscription factor (MITF) in IgE and MRGPRX2-dependent mast cell activation. Thus, MITF and MITF-dependent genes may become targets to treat IgE or MRGPRX2-dependent pathologies.158 p.application/pdfeng(c) Guo, Yanru, 2023ImmunologiaAl·lèrgiaTransducció de senyal cel·lularAnafilaxiImmunologyAllergyCellular signal transductionAnaphylaxisinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccesshttp://hdl.handle.net/10803/695239