Exuberant complex metaplastic carcinoma of the breast with sox2 expression: covering the full spectrum of ductal neoplasia of the breast

Sagasta, AmaiaSaco, AdelaRodríguez-Carunchio, LeonardoRull Ortuño, Antonio RamónRuiz, AnaCarrió, AnaFalcón Escobedo, ReynaldoFernández Ruiz, Pedro Luis2018-01-152018-01-152014-11-211699-8855https://hdl.handle.net/2445/119034We report a unusual case of a 45-year-old woman with a massive metaplastic carcinoma of the breast with a complex admixture of components including giant pleomorphic cells, sarcomatoid areas, cysts with undifferentiated stratified epithelium, squamous carcinoma foci, high grade comedo-type ductal carcinoma in situ, high grade invasive carcinoma not otherwise specified (NOS) and foci with osseous differentiation. An extensive immunohistochemical panel showed expression of both epithelial and mesenchymal markers. The self-renewal marker SOX2 was expressed in different cell types, which was interpreted as a sign of the pluripotency what can in turn explain the diversity of histologic lineages present in this tumour.6 p.application/pdfeng(c) Sociedad Española de Anatomía Patológica y Sociedad Española de Citología, 2014Càncer de mamaTumorsOncologiaBreast cancerTumorsOncologyExuberant complex metaplastic carcinoma of the breast with sox2 expression: covering the full spectrum of ductal neoplasia of the breastinfo:eu-repo/semantics/article6589022018-01-15info:eu-repo/semantics/openAccess