Bosch Hereu, LluísDelelis, OlivierSubra, FrédéricDeprez, EricWitvrow, MyriamVilarrasa i Llorens, Jaume2020-05-052020-05-052012-03-010040-4039https://hdl.handle.net/2445/158701N3 of thymidine and of 3′-azido-3′-deoxythymidine (AZT) has been linked to a tetrazole ring by condensation of nucleoside-derived 2-oxonitriles with the lithium salt of 5-acetyl-1-(4-fluorobenzyl)tetrazole (obtained by a 'click' reaction). 4-Acetyl-1,2,3-triazole, also prepared by a Cu-catalysed cycloaddition, has been similarly linked. A route for the conjugation of NRTIs with pharmacophoric elements of integrase inhibitors (INIs) has thus been disclosed.5 p.application/pdfeng(c) Elsevier Ltd, 2012VIH (Virus)Inhibidors de la integrasaIntegrase inhibitorsHIV (Viruses)info:eu-repo/semantics/article6111832020-05-05info:eu-repo/semantics/openAccess