Isoprenoid biosynthesis via the methylerythritol phosphate pathway: accumulation of 2-C-methyl-erythritol2,4-cyclodiphosphate in a gcpE deficient mutant of Escherichia coli

Seemann, MyriamCampos Martínez, NarcisoRodríguez Concepción, ManuelHoeffler, Jean FrançoisGrosdemange Billiard, CatherineBoronat i Margosa, AlbertRohmer, Michel2026-01-222026-01-222002-01-280040-4039https://hdl.handle.net/2445/225922In the bacterium Escherichiacoli, gcpE is an essential gene in the methylerythritol phosphate pathway for isoprenoid biosynthesis. Incubation of [1-3H]methylerythritol with an E. coli mutant defective in the gcpE gene resulted in the accumulation of [1-3H]methylerythritol 2,4-cyclodiphosphate. This suggests that the GCPE protein is involved in the further conversion of methylerythritol cyclodiphosphate into isoprenoids.4 p.application/pdfeng(c) Elsevier Ltd., 2002Metabolisme microbiàEscheríchia coliMicrobial metabolismEscherichia coliIsoprenoid biosynthesis via the methylerythritol phosphate pathway: accumulation of 2-C-methyl-erythritol2,4-cyclodiphosphate in a gcpE deficient mutant of Escherichia coliinfo:eu-repo/semantics/article5114772026-01-22info:eu-repo/semantics/openAccess