Tallini, Luciana R.Osorio, Edison H.Dias dos Santos, VanessaSouza Borges, Warley deKaiser, MarcelViladomat Meya, FrancescZuanazzi, José Ângelo SilveiraBastida Armengol, Jaume2018-06-122018-06-122017-12-091420-3049https://hdl.handle.net/2445/122911The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6α-hydroxymaritidine, 6β-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6α-hydroxymaritidine and 6β-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, π-π stacking and hydrophobic interactions.14 p.application/pdfengcc-by (c) Tallini, Luciana R. et al., 2017http://creativecommons.org/licenses/by/3.0/esPlantes bulbosesAlcaloidesBulb plantsAlkaloidsinfo:eu-repo/semantics/article6749962018-06-12info:eu-repo/semantics/openAccess29232852