Roca Torrent, JosepGrañena Batista, AlbertoRodríguez-Roisin, RobertAlvarez, P.Agusti-Vidal, A. (Albert)Rozman, Ciril, 1929-2022-10-132022-10-1319820040-6376https://hdl.handle.net/2445/189851Chronic graft-versus-host disease (GVHD) is a syndrome of disordered immunity in which a variety of opportunistic respiratory infections have been documented. Restrictive pulmonary disease without advanced fibrotic changes has been also known to occur; obstructive lower airways disease related to chronic GVHD has apparently not been referred to. We report a patient with chronic GVHD and irreversible airways obstruction who died in respiratory failure caused by generalised bronchiolar damage progressing over a few months. Lung function studies showed severe airflow limitation and a leftward shift in the pressure-volume curve indicating a loss of elastic recoil pressure. Postmortem pulmonary lesions were consistent with a necrotising obliterative bron chiolitis. Our purpose is to describe this unusual complication not previously reported in chronic GVHD and discuss the pulmonary mechanics.2 p.application/pdfeng(c) BMJ Publishing Group, 1982Malalties del pulmóTrasplantament d'òrgansComplicacions quirúrgiquesPulmonary diseasesTransplantation of organsComplications of surgeryinfo:eu-repo/semantics/article0137142022-10-13info:eu-repo/semantics/openAccess7071798