Riera Mestre, AntoniGarcía Morillo, José SalvadorCastelbón Fernández, JavierHernández Contreras, María EncarnaciónAguilera, PaulaJacob, JavierMartínez Valle, FernandoGuillén Navarro, EncarnaMorales Conejo, Montserrat2024-08-292024-08-292024-05-011578-1860https://hdl.handle.net/2445/214867Background: Acute hepatic porphyrias (AHPs) are a group of rare diseases that encompasses acute intermittent porphyria, variegate porphyria, hereditary coproporphyria, and 5-aminolaevulinic acid dehydratase deficiency porphyria. Symptoms of AHP are nonspecific which, together with its low prevalence, difficult the diagnosis and follow-up of these patients. Material and methods: This project used DELPHI methodology to answer PICO questions related to management of patients with AHPs. The objective was to reach a consensus among multidisciplinary porhyria experts providing answers to those PICO questions for improving diagnosis and follow-up of patients with AHP. Results: Ten PICO questions were defined and grouped in four domains: 1. Biochemical diagnosis of patients with AHP. 2. Molecular tests for patients with AHP. 3. Follow-up of patients with AHP. 4. Screening for long-term complications of patients with AHP. Conclusions: PICO questions and DELPHI methodology have provided a consensus on relevant and controversial issues for improving the management of patients with AHP. (c) 2024 The Authors. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).9 p.application/pdfengcc by-nc-nd (c) Riera Mestre, Antoni et al, 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/PorfíriaMalalties del fetgePorphyriaLiver diseasesinfo:eu-repo/semantics/article2024-06-28info:eu-repo/semantics/openAccess