Esteve-Pastor, María AsunciónGarcía-Fernández, AmayaMacías, ManuelSogorb, FranciscoValdés, MarianoRoldán, VanesaMuñiz, JavierBadimón, Lina, 1953-Roldán, InmaculadaBertomeu Martínez, VicenteCequier Fillat, Àngel R.Lip, Gregory Y.H.Anguita, ManuelMarín, Francisco2019-05-212019-05-212016-09-231346-9843https://hdl.handle.net/2445/133597Background: several bleeding risk scores have been validated in patients with atrial fibrillation (AF). The ORBIT score has been recently proposed as a simple score with the best ability to predict major bleeding. The present study aimed to test the hypothesis that the ORBIT score was superior to the HAS-BLED score for predicting major bleeding and death in "real world" anticoagulated AF patients. Methods and results: we analyzed the predictive performance for bleeding and death of 406 AF patients who underwent 571 electrical cardioversion procedures and 1,276 patients with permanent/persistent AF from the FANTASIIA registry. In the cardioversion population, 21 patients had major bleeding events and 26 patients died. The predictive performance for major bleeding of HAS-BLED and ORBIT were not significantly different (c-statistics 0.77 (95% CI 0.66-0.88) and 0.82 (95% CI 0.77-0.93), respectively; P=0.080). For the FANTASIIA population, 46 patients had major bleeding events and 50 patients died. The predictive performances for major bleeding of HASBLED and ORBIT were not significantly different (c-statistics 0.63 (95% CI 0.56-0.71) and 0.70 (95% CI 0.62-0.77), respectively; P=0.116). For death, the predictive performances of HAS-BLED and ORBIT were not significantly different in both populations. The ORBIT score categorized most patients as "low risk". Conclusions: despite the original claims in its derivation paper, the ORBIT score was not superior to HAS-BLED for predicting major bleeding and death in a "real world" oral anticoagulated AF population. (Circ J 2016; 80:2102 - 2108)7 p.application/pdfeng(c) Japanese Circulation Society, 2016Fibril·lació auricularParaventsEfectes secundaris dels medicamentsHemorràgiaCoagulacióAtrial fibrillationScreensDrug side effectsHemorrhageCoagulationinfo:eu-repo/semantics/article6647042019-05-21info:eu-repo/semantics/openAccess27557850