Navarro Brugal, GemmaBorroto Escuela, Dasiel OscarFuxe, KjellFranco Fernández, Rafael2015-04-082015-04-082014-09-301664-042Xhttps://hdl.handle.net/2445/64765Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.8 p.application/pdfengcc-by (c) Navarro et al., 2014http://creativecommons.org/licenses/by/3.0/esMalalties del sistema nerviósMembranes cel·lularsMalalties cardiovascularsProteïnes de membranaNervous system DiseasesCell membranesCardiovascular diseasesMembrane proteinsinfo:eu-repo/semantics/article6495242015-04-08info:eu-repo/semantics/openAccess25324780