Díaz Feijoo, BertaAgustí, NúriaSebio García, RaquelLópez-Hernández, AntonioSiso, MarinaGlickman, ArielCarreras-Dieguez, NuriaFuste, PereMarina, TiermesMartínez-Egea, JuditAguilera, LauraPerdomo, JuanPelaez, AmaiaLópez-Baamonde, ManuelNavarro Ripoll, RicardGimeno, ElenaCampero, BetinaTorné Bladé, AureliMartínez Palli, GracielaArguis Giménez, María José2023-03-172023-03-172022-03-232072-6694https://hdl.handle.net/2445/195560Introduction: Treatment for advanced ovarian cancer (AOC) comprises cytoreductive surgery combined with chemotherapy. Multimodal prehabilitation programmes before surgery have demonstrated efficacy in postoperative outcomes in non-gynaecological surgeries. However, the viability and effects of these programmes on patients with AOC are unknown. We aimed to evaluate the feasibility and postoperative impact of a multimodal prehabilitation programme in AOC patients undergoing surgery. Methods: This single-centre, before-and-after intervention pilot study included 34 patients in two cohorts: the prehabilitation cohort prospectively included 15 patients receiving supervised exercise, nutritional optimisation, and psychological preparation from December 2019 to January 2021; the control cohort included 19 consecutive patients between January 2018 and November 2019. Enhanced Recovery After Surgery guidelines were followed. Results: The overall adherence to the multimodal prehabilitation programme was 80%, with 86.7% adherence to exercise training, 100% adherence to nutritional optimisation, and 80% adherence to psychological preparation. The median hospital stay was shorter in the prehabilitation cohort (5 (IQR, 4-6) vs. 7 days (IQR, 5-9) in the control cohort, p = 0.04). Differences in postoperative complications using the comprehensive complication index (CCI) were not significant (CCI score: 9.3 (SD 12.12) in the prehabilitation cohort vs. 16.61 (SD 16.89) in the control cohort, p = 0.08). The median time to starting chemotherapy was shorter in the prehabilitation cohort (25 (IQR, 23-25) vs. 35 days (IQR, 28-45) in the control cohort, p = 0.03). Conclusions: A multimodal prehabilitation programme before cytoreductive surgery is feasible in AOC patients with no major adverse effects, and results in significantly shorter hospital stays and time to starting chemotherapy.12 p.application/pdfengcc-by (c) Díaz Feijoo, Berta et al., 2022https://creativecommons.org/licenses/by/4.0/Càncer d'ovariCirurgia ginecològicaQuimioteràpia del càncerMalalts de càncerOvarian cancerGynecologic surgeryCancer chemotherapyCancer patientsinfo:eu-repo/semantics/article7244142023-03-17info:eu-repo/semantics/openAccess35406407