Pertesi, MaroulioVallée, MaximeWei, XiaomuRevuelta, Maria V.Galia, PerrineDemangel, DelphineOliver, JavierFoll, MatthieuChen, SiweiPerrial, EmelineGarderet, LaurentCorre, JillLeleu, XavierBoyle, Eileen M.Decaux, OlivierRodon, PhilippeKolb, BrigitteSlama, BorhaneMineur, PhilippeVoog, EricBris, Catherine LeFontan, JeanMaigre, MichelBeaumont, MarieAzais, IsabelleSobol, HagayVignon, MargueriteRoyer, BrunoPerrot, AuroreFuzibet, Jean-GabrielDorvaux, VéroniqueAnglaret, BrunoCony-Makhoul, PascaleBerthou, ChristianDesquesnes, FlorencePegourie, BrigitteLeyvraz, SergeMosser, LaurentFrenkiel, NicoleAugeul-Meunier, KarineLeduc, IsabelleLeyronnas, CécileVoillat, LaurentCasassus, PhilippeMathiot, ClaireCheron, NathaliePaubelle, EtienneMoreau, PhilippeBignon, Yves-JeanJoly, BertrandBourquard, PascalCaillot, DenisNaman, HervéRigaudeau, SophieMarit, GéraldMacro, MargaretLambrecht, IsabelleCliquennois, ManuelVicent, LaureHelias, PhilippeAvet-Loiseau, HervéMoreno Aguado, VíctorReis, Rui ManuelVarkonyi, JuditKruszewski, MarcinVangsted, Annette JuulJurczyszyn, ArturZaucha, Jan MaciejSainz, JuanKrawczyk-Kulis, MalgorzataWątek, MarzenaPelosini, MatteoIskierka-Jażdżewska, ElzbietaGrząśko, NorbertMartínez López, JoaquínJerez, AndrésCampa, DanieleBuda, GabrieleLesueur, FabienneDudziński, MarekGarcía Sanz, RamónNagler, ArnonRymko, MarcinJamroziak, KrzysztofButrym, AleksandraCanzian, FedericoObazee, OfureNilsson, BjörnKlein, Robert J.Lipkin, Steven M.McKay, James D.Dumontet, Charles2020-10-192020-10-192019-09-010887-6924https://hdl.handle.net/2445/171340Multiple myeloma (MM) is the third most common hematological malignancy, after Non-Hodgkin Lymphoma and Leukemia. MM is generally preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS) [1], and epidemiological studies have identified older age, male gender, family history, and MGUS as risk factors for developing MM [2]. The somatic mutational landscape of sporadic MM has been increasingly investigated, aiming to identify recurrent genetic events involved in myelomagenesis. Whole exome and whole genome sequencing studies have shown that MM is a genetically heterogeneous disease that evolves through accumulation of both clonal and subclonal driver mutations [3] and identified recurrently somatically mutated genes, including KRAS, NRAS, FAM46C, TP53, DIS3, BRAF, TRAF3, CYLD, RB1 and PRDM1 [3,4,5].7 p.application/pdfengcc by (c) Pertesi et al., 2019http://creativecommons.org/licenses/by/3.0/es/Mieloma múltipleGenèticaMultiple myelomaGeneticsinfo:eu-repo/semantics/article6986922020-10-19info:eu-repo/semantics/openAccess30967618