Solé Arjó, DanielPérez Janer, FerranMancuso, Raffaella2019-01-292019-01-292015-02-100947-6539https://hdl.handle.net/2445/127700A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd(0)-catalyzed intramolecular α-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. KEYWORDS: arylation; domino reactions; nitrogen heterocycles; palladium; sulfones5 p.application/pdfeng(c) Wiley-VCH, 2015Compostos heterocíclicsCompostos de nitrogenCompostos de sofrePal·ladi (Element químic)Síntesi orgànicaHeterocyclic compoundsNitrogen compoundsSulfur compoundsPalladiumOrganic synthesisinfo:eu-repo/semantics/article6491732019-01-29info:eu-repo/semantics/openAccess25677083