Pinazo Durán, María DoloresGómez Ulla, FranciscoArias Barquet, LluísAraiz, JavierCasaroli Marano, Ricardo PedroGallego Pinazo, RobertoGarcía Medina, Jose J.López Gálvez, María IsabelManzanas, LucíaSalas, AnnaZapata, MiguelDíaz Llopis, ManuelGarcía Layana, Alfredo2018-11-122018-11-122014-01-232090-004Xhttps://hdl.handle.net/2445/126014Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (omega-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and omega-3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of omega-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and omega-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD.15 p.application/pdfengcc-by (c) Pinazo Durán, Maria D. et al., 2014http://creativecommons.org/licenses/by/3.0/esMalalties de la retinaSuplements nutritiusRetinal diseasesDietary supplementsinfo:eu-repo/semantics/article6378262018-11-12info:eu-repo/semantics/openAccess24672708