Sans de San Nicolàs, LídiaCzarnowicki, TaliAkdis, MubeccelPujol, Ramon M.Lozano-Ojalvo, DanielLeung, Donald Y. M.Guttman-Yassky, EmmaSantamaria Babí, Luis F.2025-07-292025-07-292023-07-130105-4538https://hdl.handle.net/2445/222655Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.11 p.application/pdfengcc by-nc 4.0 (c) Sans-de San Nicolàs, L., et al., 2024https://creativecommons.org/licenses/by-nc/4.0/Marcadors bioquímicsDermatitis atòpicaCèl·lules TBiochemical markersAtopic dermatitisT cellsinfo:eu-repo/semantics/article7432092025-07-29info:eu-repo/semantics/openAccess