Rodilla Sala, EnriqueLópez Carmona, Maria DoloresCortes, XaviCobos Palacios, LidiaCanales, SergioSáez, Maria CarmenCampos Escudero, SamaraRubio-Rivas, ManuelDíez Manglano, JesúsFreire Castro, SantiagoVázquez Piqueras, NuriaMateo Sanchis, ElisabethPesqueira Fontán, Paula MaríaMagallanes Gamboa, Jeffrey OskarGonzález García, AndrésMadrid Romero, VictorTamargo Chamorro, LaraGonzález Moraleja, JulioVillanueva Martínez, JavierGonzález Noya, AmaraSuárez Lombraña, AnaGracia Gutiérrez, AnyuliLópez Reboiro, Manuel LorenzoRamos-Rincón, José ManuelGómez Huelgas, RicardoSEMI-COVID-19 Network2021-05-272021-05-272021-03-03https://hdl.handle.net/2445/177711Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization.12 p.application/pdfeng(c) American Heart Association, Inc., 2021Malalties cardiovascularsInsuficiència cardíacaCOVID-19Cardiovascular diseasesHeart failureCOVID-19info:eu-repo/semantics/article2021-05-26info:eu-repo/semantics/openAccess33377393