Calderaro, JulienLetouzé, EricBayard, QuentinBoulai, AnaisRenault, VictorDeleuze, Jean-FrançoisBestard Matamoros, OriolFranco, DominiqueZafrani, Elie-SergeNault, Jean-CharlesMoutschen, MichelZucman-Rossi, Jessica2021-06-162021-06-162018-09-200028-4793https://hdl.handle.net/2445/178468To the Editor: Amyloid A (AA) systemic amyloidosis is a complication of chronic inflammatory diseases that is caused by the deposition of insoluble aggregates of cleaved N-terminal fragments of serum amyloid A (SAA) protein in tissues and organs throughout the body. Under physiologic conditions, SAA protein is produced by hepatocytes during the acute inflammatory phase in response to various cytokines such as interleukin-6. SAA is also overexpressed by neoplastic hepatocytes in inflammatory hepatocellular adenomas, a specific molecular subtype of benign liver tumors.3 p.application/pdfeng(c) Massachusetts Medical Society, 2018FetgeAmiloïdosiSèrumProteïnesLiverAmyloidosisSerumProteinsinfo:eu-repo/semantics/article6851562021-06-16info:eu-repo/semantics/openAccess30231230