Fredrick R. SchumacherSchmit, Stephanie L.Jiao, ShuoEdlund, Christopher K.Wang, HansongZhang, BenHsu, LiHuang, Shu-ChenFischer, Christopher P.Harju, John F.Idos, Gregory E.Lejbkowicz, FlavioManion, Frank J.McDonnell, KevinMcNeil, Caroline E.Melas, MarilenaRennert, Hedy S.Shi, WeiThomas, Duncan C.Berg, David J. Van denHutter, Carolyn M.Aragaki, Aaron K.Butterbach, KatjaCaan, Bette J.Carlson, Christopher S.Chanock, Stephen J.Curtis, Keith R.Fuchs, Charles S.Gala, ManishGiovannucci, Edward L.Gogarten, Stephanie M.Hayes, Richard B.Henderson, Brian E.Hunter, David J.Jackson, Rebecca D. J.Kolonel, Laurence N.Kooperberg, CharlesKüry, SébastienLaCroix, AndreaMoreno Aguado, Víctor2018-08-012018-08-012015-07-072041-1723https://hdl.handle.net/2445/124064El document inclou una pàgina final amb una correcció (corrigendum). Aquesta, per si sola, té el següent DOI: 10.1038/ncomms9739 i es va publicar al mateix vol. 6.Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.6 p.application/pdfengcc-by (c) Fredrick R. Schumacher et al., 2015http://creativecommons.org/licenses/by/3.0/esCàncer colorectalGenoma humàGenèticaColorectal cancerHuman genomeGeneticsinfo:eu-repo/semantics/article6604492018-08-01info:eu-repo/semantics/openAccess26151821