Abulí, AnnaCastells Garangou, AntoniBujanda, LuisLozano Salvatella, Juan JoséBessa i Caserras, XavierHernández-Munain, CristinaÁlvarez Urturi, CristinaPellisé Urquiza, MariaEsteban-Jurado, ClaraHijona, ElizabethBurón, AndreaMacià, FrancescGrau Cano, J. (Jaume)Guayta, Rafael (Guayta Escolies)Castellví Bel, SergiAndreu, MontserratTrilla García, AntoniPROCOLON Research Group2016-11-302016-11-302016-04-141932-6203https://hdl.handle.net/2445/104289Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population.12 p.application/pdfengcc-by (c) Abulí, Anna et al., 2016http://creativecommons.org/licenses/by/3.0/esCàncer colorectalGenètica humanaEstudi de casosMutació (Biologia)ColonoscòpiaColorectal cancerHuman geneticsCase studiesMutation (Biology)Colonoscopyinfo:eu-repo/semantics/article6645392016-11-30info:eu-repo/semantics/openAccess27078840