Paz Graniel, IndiraValle-Hita, CristinaBabio, NancySerra Majem, LluísVioque, JesúsZomeño, María DoloresCorella Piquer, DoloresPintó Sala, XavierCano-Ibañez, NaomiTur Marí, Josep A. (Josep Antoni)Cuadrado-Soto, EstherMartínez, J. AlfredoTorres-Collado, LauraGoday Arnó, AlbertFernández-Carrión, RebecaNissenshon, MarielaRiera Mestre, AntoniGarrido-Garrido, EvaBouzas, CristinaAbete, ItziarDaimiel, LidiaCornejo-Pareja, IsabelVázquez Ruiz, ZenaidaKhoury, NadinePérez Vega, Karla AlejandraSalas Salvadó, JordiDíaz-López, Andrés2025-03-122025-03-122024-09-011279-7707https://hdl.handle.net/2445/219672Objectives: The evidence on water intake in the prevention of kidney function decline is scarce at population level in well-being individuals at high cardiovascular risk. Therefore, we aimed to longitudinally evaluate the associations between total water intake and subtypes and kidney function, through estimated-Glomerular Filtration Rate (eGFR). Methods: Three-year prospective analysis conducted in 1986 older adults (aged 55-75 year) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus study. Water intake was assessed using validated beverage and food frequency questionnaires. Serum creatinine-based eGFR (SCr-based eGFR; ml/min/1.73 m2) was estimated using the CKD-EPI equation at baseline, one-year and 3-years of follow-up. Mixed-effects linear regression models were fitted to evaluate the associations between baseline total water intake and subtypes, and SCr-based eGFR over 3-years of follow-up. Results: Participants in the highest baseline tertile of total water intake, plain water and water from all fluids showed a lower decrease in SCr-based eGFR after 3-years of follow-up, compared to those in the lowest tertile. Participants with the highest tap water consumption showed a lower SCr-based eGFR decline after 1-year and 3-years of follow-up, in comparerd to participants in the lowest intake category (T3 vs. T1: β: 1.4 ml/min/1.73 m2; 95%CI: 0.5-2.3, β: 1.0; 95%CI: 0.1-2.0, respectively). Conclusions: Plain water rather than other water sources, and especially tap water, was associated with lower kidney function decline assessed through eGFR over 3-years of follow-up, in older individuals at high cardiovascular risk.9 p.application/pdfengcc by (c) Paz Graniel, Indira et al., 2024https://creativecommons.org/licenses/by/4.0/MetabolismeMalalties cardiovascularsRonyóMetabolismCardiovascular diseasesKidneyinfo:eu-repo/semantics/article7521752025-03-12info:eu-repo/semantics/openAccess39137622