Masuet Aumatell, CristinaAtouguia, Jorge2021-05-142021-05-142021-03-01https://hdl.handle.net/2445/177298Typhoid fever is a bacterial infection caused by the Gram-negative bacterium Salmonella enterica subspecies enterica serovar Typhi (S. Typhi), prevalent in many low- and middle-income countries. In high-income territories, typhoid fever is predominantly travel-related, consequent to travel in typhoid-endemic regions; however, data show that the level of typhoid vaccination in travellers is low. Successful management of typhoid fever using antibiotics is becoming increasingly difficult due to drug resistance; emerging resistance has spread geographically due to factors such as increasing travel connectivity, affecting those in endemic regions and travellers alike. This review provides an overview of: the epidemiology and diagnosis of typhoid fever; the emergence of drug-resistant typhoid strains in the endemic setting; drug resistance observed in travellers; vaccines currently available to prevent typhoid fever; vaccine recommendations for people living in typhoid-endemic regions; strategies for the introduction of typhoid vaccines and stakeholders in vaccination programmes; and travel recommendations for a selection of destinations with a medium or high incidence of typhoid fever.15 p.application/pdfengcc by (c) Masuet Aumatell et al., 2021http://creativecommons.org/licenses/by/3.0/es/AntibiòticsMalalties bacterianesResistència als medicamentsAntibioticsBacterial diseasesDrug resistanceinfo:eu-repo/semantics/article2021-05-13info:eu-repo/semantics/openAccess33301931