Balaceanu, AlexandraPérez, AlbertoDans, Pablo D.Orozco López, Modesto2019-01-112019-01-112018-06-140305-1048https://hdl.handle.net/2445/127216We analysed the basic mechanisms of signal transmission in DNA and the origins of the allostery exhibited by systems such as the ternary complex BAMHI-DNA-GRDBD. We found that perturbation information generated by a primary protein binding event travels as a wave to distant regions of DNA following a hopping mechanism. However, such a structural perturbation is transient and does not lead to permanent changes in the DNA geometry and interaction properties at the secondary binding site. The BAMHI-DNA-GRDBD allosteric mechanism does not occur through any traditional models: direct (protein-protein), indirect (reorganization of the secondary site) readout or solvent-release. On the contrary, it is generated by a subtle and less common entropy-mediated mechanism, which might have an important role to explain other DNA-mediated cooperative effects.12 p.application/pdfengcc-by-nc (c) Balaceanu, Alexandra et al., 2018http://creativecommons.org/licenses/by-nc/3.0/esADNDinàmica molecularProteïnesLligandsDNAMolecular dynamicsProteinsLigandsinfo:eu-repo/semantics/article6829252019-01-11info:eu-repo/semantics/openAccess29905860