Baeza, Inmaculada, 1970-Serna Gómez, Elena de laMezquida Mateos, GiselaCuesta, Manuel J.Vieta i Pascual, Eduard, 1963-Amoretti Guadall, SilviaLobo, AntonioGonzález-Pinto, AnaDíaz Caneja, Covadonga M.Corripio, IluminadaValli, IsabelPuig Navarro, OlgaMané Santacana, AnnaBioque Alcázar, MiquelAyora, MiriamBernardo Arroyo, MiquelCastro Fornieles, Josefinathe PEPs group2025-04-302025-04-302023-04-071018-8827https://hdl.handle.net/2445/220733To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7-35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 ± 5.1 years; 66.5% male) and 58 EOP patients (15.5 ± 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33-177] vs. 58 [21-140] days; Z = - 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31-155] vs. 30 [7-66] days; Z = - 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.12 p.application/pdfengcc-by (c) Baeza, Inmaculada, 1970- et al., 2023http://creativecommons.org/licenses/by/4.0/EdatDiagnòsticTrastorn bipolarPsicosiSímptomesEsquizofrèniaAgeDiagnosisManic-depressive illnessPsychosesSymptomsSchizophreniainfo:eu-repo/semantics/article7353592025-04-30info:eu-repo/semantics/openAccess37027026