Velasco Turbau, JavierAriza Piquer, XavierBadía, LauraBartra Sanmartí, MartíBerenguer, RamonFarràs i Soler, JaumeGallardo, JoanGarcía Gómez, JordiGasanz, Yolanda2013-12-092014-12-3120130022-3263https://hdl.handle.net/2445/48344Entecavir (BMS-200475) was synthesized from 4-trimethylsilyl-3-butyn-2-one and acrolein. The key features of its preparation are: (i) a stereoselective boron-aldol reaction to afford the acyclic carbon skeleton of the methylenecylopentane moiety; (ii) its cyclization by a Cp2TiCl-catalyzed intramolecular radical addition of an epoxide to an alkyne; and (iii) the coupling with a purine derivative by a Mitsunobu reaction.35 p.application/pdfeng(c) American Chemical Society , 2013Hepatitis BMedicaments antivíricsReacció aldòlicaÀcids nucleicsHepatitis BAntiviral agentsAldol reactionNucleic acidsinfo:eu-repo/semantics/article6262572013-12-05info:eu-repo/semantics/openAccess23678976