Théry, ClotildeWitwer, Kenneth W.Aikawa, ElenaAlcaraz, María José (Alcaraz Tormo)Anderson, Johnathon D.Andriantsitohaina, RamarosonAntoniou, AnnaArab, TaninaArcher, FabienneAtkin-Smith, Georgia K.Ayre, D. CraigNawaz, MuhammadGärtner, KathrinWeaver, AlissaPulliam, LynnNazarenko, IrinaWolfram, JoyVelot, ÉmilieRak, JanuszHosseinkhani, BaharakTorrecilhas, Ana ClaudiaKierulf, PeterVisnovitz, TamásNejsum, PeterNeri, ChristianGimona, MarioNeri, TommasoByrd, James Bryanvan Niel, GuillaumeLim, RebeccaBuck, Amy H.Bielska, EwaBauer, Natalie N.Lenassi, MetkaIsin, MustafaLibregts, Sten F.Llorente, AliciaNieuwland, RienkNimrichter, LeonardoNolan, John P.Nolte-'t Hoen, Esther N. M.Powell, Bonita H.Gupta, Gopal N.Saá, PaulaHooten, Nicole NorenWelsh, Joshua A.van Wijnen, Andre J.Jong, AmbroseGaudin, RaphaelRamirez, Marcel I.Zavec, Apolonija BedinaDriscoll, Lorraine O'Coyle, BethPerut, FrancescaLombard, Catherine A.Camussi, GiovanniKaur, SukhbirMartens-Uzunova, Elena S.Grady, Tina O’van Royen, Martin E.Loghlen, Ana O'Ochiya, TakahiroRughetti, AureliaOlivier, MartinGualerzi, AliceKim, Kwang PyoHu, GuokuSalas-Huenuleo, EdisonBlenkiron, CherieDevitt, AndrewLee, Yi Xin FionaCrescitelli, RossellaOrtiz, AlbertoWebber, Jason P.Ortiz, Luis A.Osteikoetxea, XabierSharma, ShivaniØstergaard, OlePark, JaesungShekari, FaezehCarter, David R. F.Dhondt, BertRaposo, GraçaXagorari, AngelikiGho, Yong SongPegtel, D. MichielOstrowski, MatiasRegev Rudzki, NetaHarrison, PaulSánchez, CatherineHuang, YiyaoRicklefs, Franz L.Rayyan, Morsi S.Jay, Steven M.Vilas Shelke, GaneshJovanovic-Talisman, TijanaSchiffelers, Raymond M.Saugstad, Julie A.Loyer, XavierShetty, Ashok K.Shiba, KiyotakaLeszczynska, AleksandraDas, SaumyaVan Keuren-Jensen, KendallSiljander, Pia R-M.Vizio, Dolores DiCocucci, EmanueleBreglio, Andrew M.Mariani, JacopoBusatto, SaraCoumans, Frank A. W.Silva, Andreia M.Skowronek, AgataLigeti, ErzsébetSnyder II, Orman L.Hunt, StuartChen, Chihchenvon Strandmann, Elke PoggeHolthofer, HarryGoberdhan, Deborah C. I.Pfaffl, Michael W.Mathivanan, SureshPink, Ryan C.Prada, IlariaSoares, Rodrigo PedroBosch, SteffiSódar, Barbara W.Soekmadji, CarolinaVan Deun, JanLörincz, Ákos M.Sotillo, JavierPortillo Obando, Hernando A. delCheng, LesleyJørgensen Malene MøllerLi, Isaac T.S.Vechetti Jr., Ivan J.Gilbert, CarolineStahl, Philip D.Jung, StephanieTomasini, RichardGamal-Eldin Ibrahim, AhmedBergese, PaoloRodrigues, Silvia C.Stoorvogel, WillemChen, ShuaiStott, Shannon L.Strasser, Erwin F.Watson, Dionysios C.Swift, SimonLorenowicz, Magdalena J.Benmoussa, AbderrahimWeber, ViktoriaGörgens, AndréKislinger, ThomasPeinado, HectorKalluri, RaghuTahara, HidetoshiChaudhuri, Amrita DattaTewari, MuneeshBoulanger, Chantal M.Timms, KateTixeira, RochelleXander, PatriciaIkezu, TsuneyaKlingeborn, MikaelVeit, Tiago D.Dieterich, Lothar C.Liao, KeTkach, MercedesTiwari, SwastiLowry, Michelle C.Wehman, Ann M.Mariscal, JavierVerweij, Frederik J.Vella, Laura J.Berardi, Anna C.Xu, JingyaoMorales Kastresana, AizeaWendt, SebastianWeiss, Daniel J.Yan, XiaomeiYáñez Mó, MaríaBobis-Wozowicz, SylwiaKawamura, YumiChang, Yu-TingYin, HangKlinke II, David J.Johnson, Suzanne M.Haraszti, Reka A.Robbins, Paul D.Baldacchino, ShawnYuana, YuanaBrisson, AlainPisetsky, David S.Zappulli, ValentinaMartín Jaular, LorenaBalaj, LeonoraVader, PieterMarcilla, AntonioLim, Sai KiangRussell, Ashley E.Urbanelli, Lorenavan Herwijnen, Martijn J. 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P.Minciacchi, Valentina R.Lovett, JasonVestad, BeateGardiner, ChrisDuarte, Filipe V.Hendrix, AnBreakefield, XandraDuncan, Heather M.Rohde, EvaGámez Valero, AnaBoireau, WilfridPolakovicova, IvaWauben, Marca H. M.Buzas, Edit I.Chamley, Lawrence W.Eichenberger, Ramon M.Lötvall, JanEkström, KarinAndaloussi, Samir ElInal, Jameel M.Elie-Caille, CelineMcVey, Mark J.Wheelock, Asa M.Tosar, Juan PabloJayachandran, MuthuvelGiebel, BerndErdbrügger, UtaScott, AaronBaharvand, HosseinRome, SophieFalcón Pérez, Juan ManuelMcGinnis, Lynda K.Fatima, FarahFish, Jason E.Kano, Shin-ichiFlores Bellver, MiguelGreening, David W.Fricke, FabiaKhamari, DelaramPoon, Ivan K. H.Shahaj, EriominaHill, Andrew F.Mussack, VeronikaFörsönits, AndrásFuhrmann, GregorFrelet-Barrand, AnnieHoffmann, Karl F.Kosanović, Maja M.Rouschop, Kasper M. A.Jenster, GuidoToxavidis, VasilisHolder, BethHochberg, Fred H.Vasconcelos, M. HelenaKhomyakova, ElenaViñas Muñoz, José LuisJones, Jennifer C.Jiang, LanzhouKovács, Árpád FerencBrigstock, David R.Khvorova, AnastasiaKrämer-Albers, Eva-MariaKrasemann, SusanneLinnemannstöns, KarenBorràs i Serres, Francesc EnricMaugeri, MarcoKrause, MirjaSaul, Meike J.Raffai, Robert L.Cordeiro-da-Silva, AnabelaBaxter, Amy A.Lu, QuanHandberg, AaseKurochkin, Igor V.Vukman, Krisztina V.Lemos, Debora S.Gross, Julia Christinavan Balkom, Bas W. M.Souza-Schorey, Crislyn D'Huber, VeronicaKusuma, Gina D.Radeghieri, AnnalisaKuypers, SörenLaitinen, SaaraMathieu, MathildeLangevin, Scott M.Bongiovanni, AntonellaDeville, SarahBuschmann, DominikMeckes Jr., David G.Languino, Lucia R.Wiener, ZoltánGabrielsson, SusanneWahlgren, JessicaLannigan, JoanneSahoo, SusmitaLässer, CeciliaLaurent, Louise C.Muraca, MaurizioLavieu, GregoryLay, Soazig LeMuth, Dillon C.van der Grein, Susanne G.Witte, LeonieLukomska, BarbaraShatnyeva, OlgaBebawy, MaryLee, Myung-ShinLázaro Ibáñez, ElisaMaas, Sybren L. N.Brennan, Meadhbh Á.Meehan, Katie L.Bussolati, BenedettaMalhi, HarmeetLunavat, Taral R.Chin, Andrew R.Myburgh, Kathryn H.Couch, YvonneMöller, AndreasMertens, IngeHegyesi, HargitaNajrana, Tanbir2019-06-122019-06-122018-11-232001-3078https://hdl.handle.net/2445/134921The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activitiesl Finally, a checklist is provided with summaries of key points.47 p.application/pdfeng(c) Théry et al., 2018Interacció cel·lularMembranes cel·lularsCell interactionCell membranesinfo:eu-repo/semantics/article2019-05-27info:eu-repo/semantics/openAccess30637094