Oliva, AntonioGrassi, SimonePinchi, VilmaCazzato, FrancescaColl, MònicaAlcalde, MireiaVallverdú Prats, MartaPérez Serra, AlexandraMartínez Barrios, EstefaníaCésar Diaz, SergioIglesias, AnnaCruzalegui, JoséHernández, ClaraFiol, VictoriaArbelo, ElenaDíez Escuté, NuriaArena, VincenzoBrugada Terradellas, Josep, 1958-Sarquella Brugada, GeorgiaBrugada, RamonCampuzano Larrea, Oscar2023-06-212023-06-212022-07-282077-0383https://hdl.handle.net/2445/199555Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes.13 p.application/pdfengcc by (c) Oliva, Antonio et al, 2022http://creativecommons.org/licenses/by/3.0/es/Mort sobtadaMalalties del corSudden deathHeart diseasesinfo:eu-repo/semantics/other2023-06-20info:eu-repo/semantics/openAccess932888835956023