Ibáñez Sanz, GemmaMilà, NúriaVidal Lancis, Maria CarmenRocamora, JudithMoreno Aguado, VíctorSanz Pamplona, RebecaGarcía Martínez, MontserratMSIC-SC Research Group2021-07-222021-07-222021-06-301932-6203https://hdl.handle.net/2445/179296Introduction The effectiveness of colorectal cancer (CRC) screening programs is directly related to participation and the number of interval CRCs. The objective was to analyse specific-mortality in a cohort of individuals invited to a CRC screening program according to type of CRC diagnosis (screen-detected cancers, interval cancers, and cancers among the non-uptake group). Material and methods Retrospective cohort that included invitees aged 50-69 years of a CRC screening program (target population of 85,000 people) in Catalonia (Spain) from 2000-2015 with mortality follow-up until 2020. A screen-detected CRC was a cancer diagnosed after a positive faecal occult blood test (guaiac or immunochemical); an interval cancer was a cancer diagnosed after a negative test result and before the next invitation to the program (<= 24 months); a non-uptake cancer was a cancer in subjects who declined screening. Results A total of 624 people were diagnosed with CRC (n = 265 screen-detected, n = 103 interval cancers, n = 256 non-uptake). In the multivariate analysis, we observed a 74% increase in mortality rate in the group with interval CRC compared to screen-detected CRC adjusted for age, sex, location and stage (HR: 1.74%, 95% CI:1.08-2.82, P = 0.02). These differences were found even when we restricted for advanced-cancers participants. In the stratified analysis for type of faecal occult blood test, a lower mortality rate was only observed among FIT screen-detected CRCs. Conclusion CRC screening with the FIT was associated with a significant reduction in CRC mortality.14 p.application/pdfengcc by (c) Ibáñez Sanz, Gemma et al., 2021http://creativecommons.org/licenses/by/3.0/es/Càncer colorectalCribratgeMortalitatColorectal cancerMedical screeningMortalityinfo:eu-repo/semantics/article2021-07-22info:eu-repo/semantics/openAccess34191813