Ramos-Rincón, José ManuelLópez Carmona, María DoloresCobos Palacios, LidiaLópez Sampalo, AlmudenaRubio Rivas, ManuelMartín Escalante, María DoloresCossio Tejido, Santiago deTaboada-Martínez, María LuisaMuiño Miguez, AntonioAreses Manrique, MariaMartinez Cilleros, CarmenTuñón de Almeida, CarlotaAbella Vázquez, LucyMartínez Gonzalez, Angel LuísDíez García, Luis FelipeRipper, Carlos JorgeAsensi, VictorMartinez Pascual, AngelesGuisado Vasco, PabloLumbreras Bermejo, CarlosGómez Huelgas, RicardoThe Semi-covid-19 Network2022-07-222022-07-222022-06-29https://hdl.handle.net/2445/187949Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients >= 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were >= 80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29-0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22-0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19.12 p.application/pdfengcc by (c) Ramos Rincon, Jose Manuel et al., 2022http://creativecommons.org/licenses/by/3.0/es/COVID-19SARS-CoV-2Persones gransMalalts hospitalitzatsCOVID-19SARS-CoV-2Older peopleHospital patientsinfo:eu-repo/semantics/article2022-07-21info:eu-repo/semantics/openAccess35807058