Guignard, Guillaume Michel PabloLlor Brunés, NúriaMolins i Grau, EliesBosch Cartes, JoanAmat Tusón, Mercedes2016-05-302017-04-152016-04-151523-7060https://hdl.handle.net/2445/99052A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed.4 p.application/pdfeng(c) American Chemical Society , 2016Síntesi orgànicaLactamesOrganic synthesisLactamsinfo:eu-repo/semantics/article6593302016-05-30info:eu-repo/semantics/openAccess27046224