Giménez Navarro, MónicaJunqué i Plaja, Carme, 1955-Vendrell i Gómez, PereNarberhaus, AnaBargalló Alabart, NúriaBotet Mussons, FranciscoMercader Sobrequés, José Ma.2025-10-012025-10-012006-11-270028-3878https://hdl.handle.net/2445/223458Objective: To investigate the effects of prematurity on sulcal formation. Methods: We evaluated the depth and volume of the primary olfactory sulcus (developed at 16 weeks' gestation) and the secondary orbital sulci (which start to develop at 28 weeks' gestation) in a sample of 22 adolescents with history of very-preterm birth (VPTB). We compared this preterm sample with a sample of subjects born at term and matched by age, gender, and sociocultural status. The Anatomist/BrainVISA 3.0.1 package was used to identify and quantify the sulci. In addition, voxel-based morphometry (VBM) was used to analyze possible reductions of gray and white matter in the orbitofrontal area. Results: Compared with controls, we found a significant reduction in the secondary sulci depth but not in the primary sulcus in the VPTB. VBM analysis showed reduced gray-matter volume in VPTB in the orbital region. Conclusions: Premature birth affects cerebral gyrification, and this impairment is not reversible during childhood. Identification of the specific factors involved in abnormal brain maturation may lead to effective interventions.5 p.application/pdfeng(c) American Academy of Neurology, 2006Neurologia dels nadonsInfants prematursMalformacionsCraniNeonatal neurologyPremature infantsHuman abnormalitiesSkullinfo:eu-repo/semantics/article5418032025-10-01info:eu-repo/semantics/openAccess17130415