Olmo García, María Isabel delHernández Rienda, LorenaGarcia Carbonero, RocioHernando, JorgeCustodio, AnaAnton Pascual, BeatrizGómez, MartaPalma Milla, SamaraSuarez, LorenaBellver, MartaAlonso, VicenteSerrano, RaquelValdés, NuriaMelián, MarcosFebrero, BeatrizSampedro Nuñez, Miguel AntonioBiarnes, JosefinaDíaz Pérez, José ÁngelMolina Cerrillo, JavierLópez López, CarlosMartínez Olmos, Miguel ÁngelMerino Torres, Juan FranciscoCapdevila, JaumeArgente Pla, MaríaNutrigetne Group2025-06-032025-06-032025-02-011549-490Xhttps://hdl.handle.net/2445/221346Patients with advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) have impaired nutritional and physical performance due to the cancer pathophysiology and its treatment. The NUTRIGETNE study sought to characterize the nutritional status of patients with advanced GEP-NENs in Spain. This is a cross-sectional study that included patients with advanced GEP-NENs receiving active oncological treatment. Patients had a complete physical examination, anthropometry, bioelectrical impedance, dynamometry, laboratory analysis, and a comprehensive nutritional risk assessment. Malnutrition was defined according to Global Leadership Initiative on Malnutrition (GLIM) criteria. The study included 399 patients out of the 400 planned (Pearson's chi 2; alpha 0.05). Median age was 62 years (22-83). Tumors most commonly originated in the small intestine (43.9%) and the pancreas (41.6%), 94.7% were metastatic, and 36.7%, 49.4%, and 12.5% were G1, G2, and G3, respectively. Malnutrition prevalence was 61.9% (25.8% moderate; 36.1% severe), mainly due to low muscle mass (50.9%), which was the most prevalent GLIM phenotypic criteria. Moreover, malnutrition showed a correlation with decreased hand grip strength (mean 23 vs 31.9 kg; P <.001) and phase angle (median 5o vs 5.6o; P <.001). The prevalence of sarcopenia was 15%. Malnutrition was more frequent in patients with diabetes (74.4% vs 56.7%; P <.001), NECs (82.1% vs 60.3%; P =.062), and in those treated with chemotherapy (71.2% vs 59.7%; P =.058), whereas it did not correlate with tumor origin (P =.507), histological grade (P =.781), or functionality (P =.465). Malnutrition was correlated to body mass index (BMI) (P =.015), although it was also diagnosed in a high proportion of patients with no weight loss (63%, 54.1%, and 65.1% of patients with normal BMI, overweight, and obesity, respectively). Cachexia was present in 109 (27.3%) patients. Malnutrition is very prevalent and commonly underdiagnosed in patients with GEP-NENs. It is associated with sarcopenia and a worse QoL, requiring a multifactorial nutritional assessment. Certain factors such as the presence of diabetes may require closer monitoring due to a higher risk of malnutrition.12 p.application/pdfengcc-by-nc (c) Olmo García et al., 2025http://creativecommons.org/licenses/by-nc-nd/4.0/Avaluació de l'estat nutricionalNeuroendocrinologiaTumorsNutritional status measurementNeuroendocrinologyTumorsinfo:eu-repo/semantics/article2025-05-19info:eu-repo/semantics/openAccess 39998905