Álvarez, JosepGodoy i García, PerePlans Rubio, PedroCamps, NeusCarol, MónicaCarmona i Parcerisa, GlòriaSolano, RubénRius, CristinaMinguell, SofíaBarrabeig i Fabregat, IreneSala Farré, Maria RosaRodríguez, RaquelGarcia Cenoz, ManuelMuñoz Almagro, CarmenDomínguez García, ÀngelaTransmission of Pertussis in Households Working Group2023-03-092023-03-092020-11-011080-6040https://hdl.handle.net/2445/194952We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient's household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated within <7 days, 8-14 days, 15-21 days, and >21 days after illness onset in the primary patient. We studied 476 primary index patients and their 1,975 household contacts, of whom 4.5% were later identified as having pertussis. When contacts started chemoprophylaxis within <21 days after the primary patient's symptom onset, the treatment was 43.9% effective. Chemoprophylaxis started >14 days after primary patient's symptom onset was less effective. We recommend that contacts of persons with pertussis begin chemoprophylaxis within <14 days after primary patient's symptom onset.7 p.application/pdfengDomini públic / Public domainhttp://creativecommons.org/publicdomain/zero/1.0/Tos ferinaTerapèuticaWhooping coughTherapeuticsinfo:eu-repo/semantics/article7051802023-03-09info:eu-repo/semantics/openAccess