Nagore, D.Candela, A.Bürge, M.Tamayo, E.Murie-fernández, M.Vives, M.Monedero, P.Álvarez, J.Mendez, EstherPasqualetto, AlbertoMon, T.Pita, R.Varela, M. A.Esteva, C.Pereira, M. A.Sanchez, J.Rodriguez, M. A.Garcia, A.Carmona, P.López, M.Pajares, A.Vicente, R.Aparicio, R.Gragera, I.Calderón, E.Marcos, J.m.Gómez, L.Rodríguez, J. M.Matilla, A.Medina, A.Hernández, A.Morales, L.Santana, L.Garcia, E.Montesinos, S.Muñoz, P.Bravo, B.Blanco, V.2024-10-142024-10-142024-08-012340-3284https://hdl.handle.net/2445/215766Purpose: It is unclear whether preoperative serum uric acid (SUA) elevation may play a role in the development of acute kidney injury (AKI) associated with cardiac surgery (CSA-AKI). We conducted a cohort study to evaluate the influence of preoperative hyperuricemia on AKI in patients at high risk for developing SC-AKI. Design: Multicenter prospective international cohort study. Setting: Fourteen university hospitals in Spain and the United Kingdom. Participants: We studied 261 consecutive patients at high risk of developing CSA-AKI, according to a Cleveland score >4 points, from July to December 2017. Interventions: None. Measurements and Main Results: AKIN criteria were used for the definition of AKI. Multivariable logistic regression models and propensity score-matched pairwise analysis were used to determine the adjusted association between preoperative hyperuricemia (> = 7 mg/dL) and AKI. Elevated preoperative AUS (> = 7 mg/dL) was present in 190 patients (72.8%), whereas CSA-AKI occurred in 145 patients (55.5%). In multivariable logistic regression models, hyperuricemia was not associated with a significantly increased risk of AKI (adjusted Odds Ratio [OR]: 1.58; 95% confidence interval [CI]: 0.81-3; p = 0.17). In propensity score-matched analysis of 140 patients, the hyperuricemia group experienced similar adjusted odds of AKI (OR 1.05, 95% CI 0.93-1.19, p = 0.37). Conclusions: Hyperuricemia was not associated with an increased risk of AKI in this cohort of patients undergoing cardiac surgery at high risk of developing CSA-AKI. (c) 2024 The Author(s). Published by Elsevier Espania, S.L.U. on behalf of Sociedad Espaniola de Anestesiologia, Reanimacion y Terapeutica del Dolor. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).14 p.application/pdfengcc by (c) Nagore, D. et al, 2024http://creativecommons.org/licenses/by/3.0/es/Cirurgia cardíacaMalalties del ronyóHeart surgeryKidney diseasesinfo:eu-repo/semantics/article2024-10-04info:eu-repo/semantics/openAccess38704092