Sánchez Benavides, GonzaloSalvadó, GemmaArenaza Urquijo, Eider M.Grau Rivera, OriolSuárez Calvet, MarcMilà Alomà, MartaGonzález de Echávarri, José M.Minguillón, CarolinaCrous Bou, MartaNiñerola Baizán, AidaPerissinotti, AndrésGispert, Juan DomingoMolinuevo, José LuisALFA Study2022-05-042022-05-042020-11-112352-8729https://hdl.handle.net/2445/185358Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status. Results: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003). Discussion: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.10 p.application/pdfengcc-by-nc (c) Sánchez Benavides, Gonzalo et al., 2020https://creativecommons.org/licenses/by-nc/4.0/Malaltia d'AlzheimerAmiloïdosiTrastorns de la cognicióSímptomesDiagnòsticAlzheimer's diseaseAmyloidosisCognition disordersSymptomsDiagnosisinfo:eu-repo/semantics/article7230972022-05-04info:eu-repo/semantics/openAccess33204815