McGrath, John J.McLaughlin, K. A.Saha, SukantaAguilar-Gaxiola, SergioAl-Hamzawi, Ali ObaidAlonso, JordiBruffaerts, RonnyGirolamo, Giovanni deJonge, Peter deEsan, O.Florescu, Silvia E.Gureje, OyeHaro Abad, Josep MariaHu, ChiyiKaram, Elie GeorgesKovess-Masfety, VivianeLee, Soon YeunLepine, Jean PierreLim, Carmen C. W.Medina Mora, Maria ElenaMneimneh, Z.Pennell, Beth-EllenPiazza, MarinaPosada Villa, JoséSampson, Nancy A.Viana, Maria CarmenXavier, MiguelBromet, Evelyn J.Kendler, Kenneth S.Kessler, Ronald C.2018-02-262018-02-262017-01-090033-2917https://hdl.handle.net/2445/120251Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations. METHOD: We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models. RESULTS: Exposure to CAs was common, and those who experienced any CAs had increased odds of later PEs [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.9-2.6]. CAs reflecting maladaptive family functioning (MFF), including abuse, neglect, and parent maladjustment, exhibited the strongest associations with PE onset in all life-course stages. Sexual abuse exhibited a strong association with PE onset during childhood (OR 8.5, 95% CI 3.6-20.2), whereas Other CA types were associated with PE onset in adolescence. Associations of other CAs with PEs disappeared in adolescence after adjustment for prior-onset mental disorders. The population attributable risk proportion (PARP) for PEs associated with all CAs was 31% (24% for MFF). CONCLUSIONS: Exposure to CAs is associated with PE onset throughout the life-course, although sexual abuse is most strongly associated with childhood-onset PEs. The presence of mental disorders prior to the onset of PEs does not fully explain these associations. The large PARPs suggest that preventing CAs could lead to a meaningful reduction in PEs in the population.26 p.application/pdfeng(c) Cambridge University Press, 2017Malalties mentalsInfantsMental illnessChildreninfo:eu-repo/semantics/article6678902018-02-26info:eu-repo/semantics/openAccess28065209