Puig, PereErill, NadinaTerricabras, MartaSubirana, IsaacGonzález-García, JuditAsensi-Puig, AdriàDonovan, Michael J.Mengual Brichs, LourdesAgulló-Ortuño, M. TeresaOlivan Riera, MireiaAlcaraz Asensio, AntonioLópez-Martín, José A.Torres, Inés deRodríguez Peralto, José LuisRodríguez-Antolín, AlfredoMorote, JuanGonzález-Rumayor, Víctor2020-06-042020-06-042019-01-301756-0500https://hdl.handle.net/2445/164367Objectives: To apply a systems pathology-based approach to the quantification of nuclear Active β-catenin and human leukocyte antigen class I, and assess the biomarker involvement in a cohort of prostate tumor patients. Results: The systems pathology approach applied allows a precise quantification of the marker expression in the different cell compartments as well as the determination of the areas that coexpress two markers. Our data shows that the accumulation of β-catenin in the nuclear compartment is significantly decreased in the adjacent normal areas when compared to tumor of the same patients (p < 0.001). In conclusion, the application of this novel multiple immunofluorescence assay demonstrates that the upregulation of Active β-catenin is a relatively common feature of prostate tumor development, and further supports the activation of the Wnt/β-catenin pathway in prostate cancer progression.5 p.application/pdfengcc-by (c) Puig, Pere et al., 2019http://creativecommons.org/licenses/by/3.0/esMarcadors bioquímicsCàncer de pròstataProteïnesBiochemical markersProstate cancerProteinsinfo:eu-repo/semantics/article6988842020-06-04info:eu-repo/semantics/openAccess30700322